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TEZSPIRE® is the first & only anti-TSLP mAb.*
The mechanism of action of TEZSPIRE® in asthma has not been definitively established.1
TEZSPIRE® is a human monoclonal antibody that binds to thymic stromal lymphopoietin (TSLP) and inhibits its interaction with the heterodimeric TSLP receptor. TSLP is an epithelial cytokine that occupies an upstream position at the top of the asthma inflammatory cascade. Due to its upstream position, TSLP is involved in a broad spectrum of airway inflammation processes.1
Inhibiting the biological activity of TSLP with TEZSPIRE® decreases a broad spectrum of downstream biomarkers and cytokines involved in inflammation (e.g., blood eosinophils, IgE, FeNO, IL-5, and IL-13).1
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trial findings
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for TEZSPIRE®
* Comparative clinical significance has not been established.
FeNO, fractional exhaled nitric oxide; lgE, immunoglobulin E; IL, interleukin; mAb, monoclonal antibody; TSLP, thymic stromal lymphopoietin
References:
Last reviewed: Sept 2024
TEZSPIRE® and the logo are trademarks of Amgen Inc. and the Amgen logo is a registered trademark of Amgen Inc., used under license by AstraZeneca Canada Inc.
© 2024 AstraZeneca Canada Inc. All rights reserved.
AstraZeneca and the AstraZeneca logo are registered trademarks of AstraZeneca AB, used under license by AstraZeneca Canada Inc.
TEZSPIRE® and the logo are trademarks of Amgen Inc. and the Amgen logo is a registered trademark of Amgen Inc., used under license by AstraZeneca Canada Inc.
© 2024 AstraZeneca Canada Inc. All rights reserved.
AstraZeneca and the AstraZeneca logo are registered trademarks of AstraZeneca AB, used under license by AstraZeneca Canada Inc.
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